investigation of transforming growth factor-β1 gene polymorphisms among iranian patients with chronic hepatitis c
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Investigation of Transforming Growth Factor-β1 Gene Polymorphisms Among Iranian Patients With Chronic Hepatitis C
BACKGROUND Chronic hepatitis C infection is caused by the hepatitis C virus (HCV), and its clinical complications include liver cirrhosis, liver failure, and hepatocellular carcinoma.Transforming growth factor-β1 (TGF-β1) is an important cytokine in cell growthand differentiation, angiogenesis, extracellular matrix formation, immune responseregulation, and cancer development and progression. ...
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BACKGROUND Several cytokines including transforming growth factor (TGF)-β1 have been suggested to be involved in the pathogenesis of fibrosis in chronic hepatitis C. We examined the changes of TGF-β1 serum levels and their predictive value in patients with chronic hepatitis C under antiviral therapy. METHODS We included 84 patients with chronic hepatitis C who were treated with pegylated inte...
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Background: The aim of this retrospective study is to investigate the cumulative live birth rate (CLBR) following one or more completed in vitro fertilization (IVF) cycles (up to 6 cycles) stratified by maternal age and type of infertility. Materials and Methods: In this retrospective study, five hundred forty-seven women who received 736 fresh ovarian stimulation/embryo transfer cycles between...
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Material and methods. The sample consisted of 301 healthy unrelated individuals, and 132 patients with periodontitis. All individuals were of Macedonian origin and nationality and residents of different regions of the Republic of Macedonia. DNA was isolated from peripheral blood leukocytes by the phenol-chlorophorm extraction method. Cytokine polymorphism genotyping was performed by PCR-SSP (He...
متن کاملlack of association between transforming growth factor beta 1 -509c/t and +915g/c polymorphisms and chronic hepatitis b in iranian patients
objectives in this study, the association of tgf-β1 +915g/c and -509c/t gene polymorphisms with chronic hepatitis b was evaluated in iranian patients. materials and methods a population-based case–control study was conducted in taleghani hospital, tehran. a number of 220 patients with chronic hepatitis b and the same number of healthy control subjects were designated the case and the control gr...
متن کاملLack of Association Between Transforming Growth Factor Beta 1 -509C/T and +915G/C Polymorphisms and Chronic Hepatitis B in Iranian Patients
BACKGROUND Chronic hepatitis B is one of the world's major health concerns [corrected]. The etiological agent of this infection is hepatitis B virus (HBV), which can evade the immune system response. Transforming growth factor beta 1 (TGF-β1) can act against HBV by suppressing the viral replication. The TGF-β1 also plays an important role in preventing liver damage in chronically HBV infected p...
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عنوان ژورنال:
hepatitis monthlyجلد ۱۱، شماره ۱۱، صفحات ۹۰۱-۹۰۶
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